Endocrine Abstracts

Introduction: Cyclooxygenase-2 (COX-2), an inducible enzyme in prostaglandin synthesis, plays a major role in the pathogenesis of sporadic colorectal carcinoma (CRC). COX-2 inhibitors reduce the mortality from sporadic CRC. Acromegaly is associated with an increased risk of CRC, with a preponderance of right sided disease, but COX-2 protein is reduced or absent in acromegalic normal and malignant colonic mucosa. The mechanisms responsible for this are unknown.Aims: (i) To ...

Introduction: Metabolic disturbances that are common in polycystic ovary syndrome (PCOS), represent a risk factor for cardiovascular disease. The aim of this study was to define contribution of obesity for the development of dyslipidemia and insulin resistance in PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. We evaluated 158 women with PCOS who were divided into two subgroups according to body mass index (BMI) cut off value 25 kg/m2</s...